RNF213 and coronary artery disorder: In contrast, the absolute values of the effect sizes of these variants showed clear differences; most of the variants (36 of 41 variants, binomial P = 7.8 × 10−7) showed higher β coefficients in non-VSA CAD (median, 1.94 folds) than VSA, except for rs112735431 in the RNF213 gene, which showed a considerably higher β coefficient in VSA than in non-VSA CAD (1.86 folds) (Figure 2A and eFigure 5 in Supplement 1).