VKORC1 and early-onset autosomal dominant Alzheimer disease: For example, LY6H (lifetime smoking β, 0.02; 95% CI, 0.01-0.03; P = 2.37 × 10−6), RIT2 (lifetime smoking β, 0.02; 95% CI, 0.01-0.03, P = 1.05 × 10−5) (Figure 5B and D), AKT5, SNF8, and DOCK4, while targets, like VKORC1 and ACP1, had several phenome-wide MR associations suggesting possible adverse effects, such as increased risk of Alzheimer disease (VKORC1) and malignant melanoma (ACP1).