EGFR and Mcl-1 mRNA and protein expression levels were significantly higher in HNC tissues than in normal or margin tissues using datasets obtained from the Gene Expression Omnibus (GEO), the Cancer Genome Atlas (TCGA), and Clinical Proteomic Tumor Analysis Consortium (CPTAC) (Additional File 1A–E, G–K). The gene discussed is EGFR; the disease is neoplasm.