Thus, it will be increasingly important in the future to assess the presence of the BCR/ABL1 protein outside the clonal ALL population when applicable and to ensure the simultaneous use of VDJ MRD assessment methods (NGS/RQ-PCR) in adult Ph + ALL to guide therapeutic decisions (i.e., RT-qPCR should never be used in isolation for MRD analysis in Ph + ALL). Here, BCR is linked to acute lymphoblastic leukemia.