The authors not only presented evidence of SYVN1 involvement in F508del-CFTR proteostasis in HeLa and CFBE41o- transfected cells but also demonstrated partial restoration of F508del-CFTR-mediated Cl− transport in primary cultures of human cystic fibrosis airway epithelia upon downregulation of SYVN1. The gene discussed is CFTR; the disease is cystic fibrosis.