NEDD4L and pancreatic adenocarcinoma: In 2009, NEDD4L (also known as Nedd4-2) was identified as another ubiquitin ligase capable of interacting with both WT- and F508del-CFTR in CFPAC-1 cells (a pancreatic adenocarcinoma cell line from a patient carrying F508del-CFTR) [58].