TP53 and B-cell chronic lymphocytic leukemia: Additionally, while newly diagnosed Chinese patients with CLL and Western patients have similar frequencies of del(17p) (7.8% [6] vs. 5–8% [5], respectively) and TP53 mutations (8.2% [6] vs. 4–8% [7]), the frequency of unmutated immunoglobulin heavy chain variable region in untreated CLL is lower in Chinese patients (31% [6] vs. 48% [8]).