CD47 blockade can enhance the anti‐tumor efficacy of STING agonists.[33] Based on our findings of macrophage infiltration and STING activation in tumor‐associated macrophages (TAMs) after treatment, we further investigated whether combining biohybrid bacteria‐mediated PTT with CD47 nanobody could synergistically inhibit tumor growth. This evidence concerns the gene CD47 and neoplasm.