The photothermal effect mediated by the CR dye from bacteria not only induced cancer cell death but also triggered the release of internal nucleic acids from both the bacteria and tumor cells, which in turn activate the STING pathway in macrophages within the TME, which resulted in increased infiltration of macrophages, rather than T cells, into the TME, and create a cascading effect. The gene discussed is STING1; the disease is cancer.