CDH17 and familial pancreatic carcinoma: CDH17 is also highly expressed in pancreatic cancer (Figure S1, Supporting Information), and pancreatic cancer is characterized by atypical hyperplastic glands in a stroma‐enriched microenvironment (connective tissue hyperplasia), which is hypovascularized and highly hypoxic.[20] This unique property of pancreatic cancer renders it difficult for drug penetration.[21] Therefore, we further examined whether Nb289‐engineered bacteria could efficiently home to pancreatic cancer.