Notably, Nb289‐MG1655‐CR plus irradiation showed promising efficacy in inhibiting ASPC1 pancreatic cancer and significantly extended the survival of mice compared to C9‐MG1655‐CR plus irradiation or vehicle control (Figure 6H–J), suggesting that CDH17 nanobody Nb289 markedly enhances the penetration of MG1655 bacteria conjugated with CR. The gene discussed is CDH17; the disease is familial pancreatic carcinoma.