Additionally, we aimed to determine if Nb289‐MG1655‐CR plus irradiation could have an impact on the TME by stimulating exogenous materials released from lysed bacteria upon heating.[27] For this, we selected Colon26 colorectal cancer cells derived from BALB/c mice, which highly express murine CDH17, to establish a syngeneic tumor model in immunocompetent BALB/c mice for targeted imaging and therapy using Nb289‐MG1655‐CR bacteria. Here, CDH17 is linked to neoplasm.