This indicates that DNA is more important than proteins in the supernatant, and specific proteins may facilitate STING activation by forming complexes with DNA.[32] To confirm these finding in tumor tissues, the STING pathway‐associated gene panel was determined in the mouse tumor tissues from PTT‐treated animals in Figure 7C, showing that Nb289‐MG1655‐CR mediated PTT led to significant upregulation of key transcription factors involved in STING pathway activation and downstream target genes when compared with PBS or C9‐MG1655‐CR (Figure 8J). The gene discussed is STING1; the disease is neoplasm.