Notably, Nb289‐MG1655‐CR plus irradiation showed promising efficacy in inhibiting ASPC1 pancreatic cancer and significantly extended the survival of mice compared to C9‐MG1655‐CR plus irradiation or vehicle control (Figure 6H–J), suggesting that CDH17 nanobody Nb289 markedly enhances the penetration of MG1655 bacteria conjugated with CR. Here, CDH17 is linked to pancreatic neoplasm.