Since CDH17 in cancer cell membrane could mediate the internalization of the corresponding nanobodies and nanobody‐modified extracellular vesicles,[11, 19] we also demonstrated here that Nb289‐engineered bacteria MG1655 could be efficiently internalized by CDH17‐positive cancer cells in vitro and in vivo (Figure S16A,B, Supporting Information). The gene discussed is CDH17; the disease is cancer.