Biomaterial‐mediated mild PTT has been shown to shape the TME primarily by activating adaptive immunity and enhancing the efficacy of immunotherapies using PD‐1 and PD‐L1 antibodies.[28, 44] Interestingly, we found that Nb289‐MG1655‐CR combined with irradiation remarkably induced the infiltration of macrophages and promoted DC maturation, without a significant increase in T‐cell infiltration in a syngeneic murine Colon 26 tumor model (Figure 7). This evidence concerns the gene CD274 and neoplasm.