CGAS and inflammatory bowel disease: Radiation‐induced DNA damage is a key mechanism responsible for radiation cytotoxicity.[23] As a cytosolic DNA sensor, cGAS binds to DNA and catalyzes cGAMP synthesis, eventually driving the expression of IFN‐I.[17b] Irradiation can activate the cGAS‐STING pathway in the intestine, which triggers acute inflammation.[11, 29] In addition, activation of the cGAS‐STING pathway is also characteristic of inflammatory bowel disease.[7, 8, 11] Therefore, the cGAS‐STING pathway is an important target for alleviating radiation enteritis and inflammatory bowel disease.