According to the SHAP explanation results, the five most highly ranked features for NPC and HC differentiation were monocytes, PD‐1+ CD4 T cells, memory B cells, CTLA4+ CD4 Treg cells and PD‐1+ CD8 T cells, the levels of which significantly differed between the NPC and HC groups. Here, CD4 is linked to nasopharyngeal carcinoma.