Although the PI3Kγ inhibitor 3‐MA had an inhibitory effect on the PI3K/Akt/mTOR pathway, it also had an inhibitory effect on Vps34, generally reducing the level of autophagy and aggravating the degree of eosinophilic inflammation and tissue remodeling in nasal polyps. Here, PIK3C3 is linked to Nasal polyposis.