Compared with the SLE‐C control group, the population of CD4 and CD8 effector T cells experienced significant reductions in the H‐D group (CD4: 61.40 ± 8.62% vs. 74.77 ± 5.20%, p = .0205; CD8: 36.1 ± 1.75% vs. 46.75 ± 4.37%, p = .0009; Figure 6E,G). Here, CD8A is linked to systemic lupus erythematosus.