NES and infection: Neither CMV-Cre Ifit2 fl/fl mice (Fig. 2A) nor Nes-Cre Ifit2 fl/− mice (Fig. 2B) survived beyond 6 days after intranasal infection with a low dose [400 plaque-forming units (pfu)] of VSV, whereas 60% of Ifit2 fl/fl mice, without Cre, survived beyond 14 days post infection.