Although it's generally agreed upon that DAM plays a protective role in slowing down AD progression, recent studies have identified distinct subsets within DAM, categorized as a dual role for TREM2 in AD pathogenesis; “pro‐inflammatory” and “anti‐inflammatory.” Analysis of the upstream regulators of major DAM markers reveals the contribution of both pro‐ and anti‐inflammatory signaling pathways to DAM formation. This evidence concerns the gene TREM2 and Alzheimer disease.