A panel of four cell lines (Figure 1a) representing some of the molecular, cellular and genetic heterogeneity observed in CRC, namely microsatellite instability (MSI)/stability (MSS) (Flecchia et al., 2022); consensus molecular subtype (CMS) (Guinney et al., 2015; Sveen et al., 2018); proteomic signature (Wang et al., 2017); and oncogene/tumour suppressor status (Ahmed et al., 2013), was investigated to determine whether these cells all secrete more Rab11a‐exosomes under nutrient stress. This evidence concerns the gene RAB11A and neoplasm.