Given emerging evidence that VIP may have a role in migraine induction, based on the more recent triggering data,137 and demonstration of elevated blood levels interictally in migraine,154 as well as ictally in both blood and saliva,155 contrary to what had been thought previously, further targeting of VPAC1/2 receptors is likely to be an avenue of future interest. This evidence concerns the gene VIPR1 and migraine disorder.