Intriguingly, the prevalence of APC and KRAS mutations, which are well‐known CRC drivers, was comparable between CRCs with and without PLK1 mutations; however, TP53 mutations were more prevalent in PLK1 wild‐type CRCs while considerable mutated genes were enriched in PLK1‐mutated CRCs (Figure 2C). Here, PLK1 is linked to colorectal carcinoma.