In the CRC cohort, compared to CRC harbouring PB1/2 mutations, PLK1 truncating mutations appeared to be more prevalent in the Pkinase domains or the regions other than Pkinase and PB1/2 (Other) (p = 0.05, Figure 1C), with no obvious differences between MSI and MSS CRCs (Figure S1C). Here, PLK1 is linked to colorectal carcinoma.