Myokines, such as osteopontin and irisin, are associated with cancer development and progression in humans,7, 8 and preclinical models implicate myokines, such as oncostatin M and interleukin‐6 (IL‐6), in cancer cell growth, migration, invasion, apoptosis and angiogenesis.9, 10. The gene discussed is FNDC5; the disease is cancer.