Mechanistically, the 3D‐Exos enriched with miR‐132‐3p and miR‐125b‐5p could induce Treg cells differentiation and suppress oxidative stress‐induced apoptosis by targeting Sirt1 and Bak1 respectively, thereby protecting melanocytes from oxidative and immune destruction, and ultimately alleviating the progression of vitiligo. Here, BAK1 is linked to vitiligo.