Tregs helps to keep the immune response in balance by suppressing the activation of autoreactive CD8+T cells.[1] It is found that increasing the number of Tregs result in a continuous remission of depigmentation in mice with vitiligo,[23] indicating that replenishing Tregs can repair the disrupted autoimmune tolerance and is a promising therapeutic method for vitiligo. This evidence concerns the gene CD8A and vitiligo.