TP53 and myocardial ischemia: It has previously been reported Bak1 plays a pro‐apoptotic role as a direct target gene of miR‐125b‐5p.[45b] Hypoxia‐induced MSCs‐Exos inhibits the expression of Bak1 and tumor protein p53 through miR‐125b, to improve myocardial apoptosis and promote myocardial ischemia repair.[46] The results above imply that miR‐125b‐5p in 3D‐Exos might reduce oxidative stress and apoptosis of vitiligo melanocytes by inhibiting Bak1 expression.