In agreement with our findings, LD accumulation has been observed in a subset of patients with malignant hyperthermia and early‐onset hypotonia where RyR mutations cause pathogenic Ca2+ leaks.[73, 74] However, greater lipid‐handling abnormalities are seen in patients with LGMD2B compared to RyR myopathies. This evidence concerns the gene RYR1 and Malignant hyperthermia.