KDR and hypertensive disorder: We reviewed reports of VEGF inhibitor–associated aortic dissection and found that not all cases describing TKI-induced aortic dissection reported that patients had hypertension before the onset of aortic dissection, which was consistent with the patient case that we reported.2,3,9,15 Based on this fact, we speculated that the VEGF–VEGFR signal pathway with ICB plays an important role in AAS in addition to hypertension.15