He did not report recurrence of his gynecomastia nor mastodynia on spironolactone 37.5 mg daily, achieving an average home BP < 135/85 mm Hg, a satisfactory renin concentration of 12 mU/L, a stable average eGFR of 40 mL/min/m2, and normokalaemia (≤5.2 mmol/L). Here, REN is linked to mastodynia.