This study measured iron content and the expression of ferroptosis-related genes including solute carrier family 7 member 11 (SLC7A11, also known as xCT), GPX4, transferrin receptor (TFRC), and nuclear factor erythroid 2-related factor 2 (Nrf2) in keloid tissues, and explored the role of ferroptosis in the occurrence and development of keloid using a ferroptosis inhibitor ferrostatin-1 (Fer-1) and a ferroptosis activator erastin, hoping to provide experimental data for the study of the pathogenesis of scar tissue. Here, NFE2L2 is linked to keloid.