Omalizumab, a monoclonal antibody against human IgE, can be used for moderate-to-severe persistent allergic asthma in children 6 years and older with asthma uncontrolled by ICS + LABA therapy alone (The Respiratory AllergyAsthma Group of Chinese Thoracic Society and Chinese Medical Association, 2019). The gene discussed is IGHE; the disease is allergic asthma.