Additionally, mast cells express receptors for neuropeptides and neurotransmitters, thus playing a key role in the interplay between allergic diseases and neurological comorbidities (Greene et al., 1985; Bienenstock et al., 1988; Stead et al., 1989; Kiernan, 1990; Williams et al., 1997), while IgE high-affinity receptors and other T2 receptors are expressed on sensory (Kiernan, 1990) or enteric neurons and are functional and able to transmit signals to the CNS (van der Kleij et al., 2010; Crosson et al., 2021). This evidence concerns the gene IGHE and allergic disease.