IGHE and asthma: Although the guidelines do not recommend omalizumab for patients with a total IgE >1,500 IU/mL, some studies have shown that the use of omalizumab in pediatric asthma patients with high levels of IgE can help children achieve asthma control and reduce acute attacks with some degree of clinical benefit (Maselli et al., 2013; Wang et al., 2018b; Hutyrová et al., 2018; National Clinical Medical, 2021).