Compared to GA-MOF(−), MOF(−) and MOF(+), GA-MOF(+) resulted in smaller tumor sizes and a more inflammatory TME with significantly more infiltration of myeloid cells (CD45+CD11b+), helper T cells (CD45+CD3+CD4+), effector T cells (CD45+CD3+CD8+CD44+CD62L−) and central memory T cells (CD45+CD3+CD8+CD44+CD62L+) and downregulation of regulatory T cells (Treg, CD45+CD3+CD4+FOXP3+CD25+) (Fig. 4d, Fig. S14). Here, ISG20 is linked to neoplasm.