ATG5 and acute myeloid leukemia: ATG5-dependent autophagy promotes the development of AML, while knockdown of ATG5 improves AML sensitivity to chemotherapeutic agents (Liu et al., 2016; Wang et al., 2023), ATG5 also mediates the potential differentiation capacity of AML MSCs and the cell cycle distribution, which leads to autophagy and improves AML chemosensitivity (Li Y. et al., 2020).