ATG5 and acute myeloid leukemia: Decitabine (DAC) not only has the effect of inhibiting the methylation of DNA, but also promotes the formation of autophagosomes in AML cells by down-regulating the expression of TIGAR, which leads to the upregulation of ATG3, ATG5, LC3, and Beclin-1 proteins and the downregulation of p62 (Li et al., 2021).