SPAG6 and acute myeloid leukemia: Myelodysplastic syndromes (MDS) have a very high risk of transformation into AML (Corey et al., 2007), and increased expression of sperm-associated antigen 6 (SPAG6) has been detected in patients with AML transformed by MDS and in patients with new-onset AML (Steinbach et al., 2006).