miRNAs have a wide range of roles in leukemia, among which, miR-145 enhances the sensitivity of ALL cell lines to glucocorticoids, which is achieved by promoting the expression of Beclin-1 and Bax genes and inhibiting the expression of Bcl-2 genes to induce autophagy and apoptosis production (Long et al., 2020). The gene discussed is BCL2; the disease is acute lymphoblastic leukemia.