hnRNPK can bind to Beclin-1 in Ph(+) ALL, and upregulation of hnRNPK promotes the generation of autophagic vesicles in Ph(+) ALL cells, which enhances the resistance of Ph(+) ALL cells to imatinib (Zhang J. et al., 2022). The gene discussed is BECN1; the disease is acute lymphoblastic leukemia.