ULK1 has been shown to be involved in the generation of its autophagy in many diseases, for example, in pancreatic cancer, NEDD4L can interact with ULK1 to reduce ULK1 expression to inhibit autophagy and mitochondrial metabolism, which in turn inhibits the survival of pancreatic cancer cells (Lee et al., 2020). This evidence concerns the gene NEDD4L and familial pancreatic carcinoma.