In vestibular schwannoma (VS), a tumor arising from Schwann cells lining the cochleovestibular cranial nerve, the tumor microenvironment (TME) plays a key role in influencing its natural history.1,2 As the 4th most prevalent intracranial neoplasm, VS is also the hallmark tumor of NF2-related Schwannomatosis (NF2-SWN), a devastating genetic tumor disposition syndrome with no effective cure. Here, NF2 is linked to neoplasm.