While adherent tumors may be larger than nonadherent tumors overall, in a size-matched sub-analysis of adherent and nonadherent tumors (n = 5 per group, tumor diameter 2.7 vs 2.7 cm), adherent VS still secreted higher levels of MMP9 (87.4 vs 2.6 ng/ml, P = .012) (Supplementary Table 5). This evidence concerns the gene MMP9 and neoplasm.