CDH2 and metastatic malignant neoplasm: Furthermore, TNF-α also led to upregulation of αvβ3 integrin and a 3-fold increase in expression of the cell–cell adhesion molecule N-cadherin in HEI-193 cells (Supplementary Figure 5C and D), 2 cell-surface proteins whose overexpression is observed in metastatic cancers.44,45