AKT1 and colorectal carcinoma: As shown in Figure 3F(Fig. 3), western blot analysis revealed that the significant induction in protein levels of CAF-specific markers α-smooth muscle actin (α-SMA) and fibroblast-activation protein (FAP) in fibroblasts induced by 100 μg/mL SW480 CRC-Exo partly depends on Akt activation.