Overexpression of miR-4262 inhibits OPN-mediated invasion, while reduced miR-4262 promotes invasion of OS cells. In addition, upon the growth of a tumor size larger than 1 cm and the onset of hypoxia within the tumor cells, there is an increase in the expression of VEGF (vascular endothelial growth factor), which is dependent on HIF1α. Here, HIF1A is linked to neoplasm.