SPP1 and neoplasm: Overexpression of miR-4262 inhibits OPN-mediated invasion, while reduced miR-4262 promotes invasion of OS cells. In addition, upon the growth of a tumor size larger than 1 cm and the onset of hypoxia within the tumor cells, there is an increase in the expression of VEGF (vascular endothelial growth factor), which is dependent on HIF1α.