Abbreviations: OS: osteosarcoma; RUNX-2: Runt-related transcription factor 2; SaOS: sarcoma osteogenic; MG63: human osteoblastic cell line; U2OS: human bone osteosarcoma epithelial cell; HOS: human osteosarcoma cell; G292: human osteosarcoma cell; 143B: cell line derivative of the HOS cell line; miR-4262: microRNA-4262; MMP-2/9: matrix metalloproteinases-2/9; RPMI 1640: Roswell Park Memorial Institute 1640. Here, RUNX2 is linked to bone osteosarcoma.