IST: immunosuppressive therapy; AST: aspartate aminotransferase; ALT: alanine aminotransferase; BUN: blood urea nitrogen; MPO-ANCA: myeloperoxidase anti-neutrophil cytoplasmic antibodies; PR3-ANCA: proteinase-3-anti-neutrophil cytoplasmic antibodies; SS: Sjogren syndrome; RNP: ribonucleoprotein; ACE: angiotensin-converting enzyme; sIL2R: soluble IL2 receptor; WBC: white blood cell; RBC: red blood cell. The gene discussed is MPO; the disease is Sjogren syndrome.