Cancer-associated fibroblasts (CAF) from invasive tumors secrete IGF2, which is due to the release of β fibroblast growth factor (βFGF) and transforming growth factor β (TGFβ) from epithelial tumor cells resulting in fibroblasts activation caused by the release of βFGF and TGFβ (23). The gene discussed is TGFB1; the disease is cancer.