Subsequent exploration of expression variations in these genes across diverse HPV statuses uncovered a significant divergence in the expression of TDO2 and ZDHHC9 between patients with HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma, with lower expression observed in HPV-positive individuals (Figure 8A). Here, ZDHHC9 is linked to oropharynx squamous cell carcinoma.