FOXP3 and neoplasm: To further characterize the intra-tumoral immune response against PCa and assess the potential prognostic value of TIL, we analyzed the infiltration of CD3+, FoxP3+ and CD45RO+ cells in the tumor core, tumor margin and the adjacent normal-like epithelium area in radical prostatectomy specimens from 98 PCa patients at increased risk of recurrence and with very mature long-term clinical follow-up.