A Norwegian study carried out on 535 primary PCa displayed on TMA, showed that in multivariate Cox regression analysis, a higher density of CD8+ lymphocytes in both tumor epithelial and tumor stromal areas taken as one single value, was an independent negative prognostic factor for BCR-free survival (HR= 1.565, CI 95%= 1.132–2.165, p= 0.007). Here, CD8A is linked to posterior cortical atrophy.