The patient was diagnosed with overlap syndrome of NMOSD with AGO-Abs and was administered an intravenous pulse therapy regimen of methylprednisolone (1 g/day for 3 days, 500 mg/day for 3 days, 250 mg/day for 3 days, and 120 mg/day for 3 days, followed by tapering oral prednisone tablets at 60 mg/day) based on expert consensus on the treatment of NMOSD in China (13). Here, FBXW7 is linked to overlapping connective tissue disease.