Target modules (TMs) are AMs tagged with a short peptide sequence, such as the E5B9 epitope of the La/SS-B nuclear protein, which is recognized by an AdCAR bearing an anti-La scFv as its extracellular domain: the corresponding AdCAR platform, known as the “UniCAR” system, has shown promise in preclinical models of various malignancies, including AML, B-cell NHL, disialoganglioside GD2+ neuroblastoma, and sialyl-Tn (STn)+ breast cancer (17–22). This evidence concerns the gene SSB and acute myeloid leukemia.