Moreover, patient-derived TanCAR-T cells redirected against HER2 and the α2 subunit of the interleukin (IL)-13 receptor (HER2 x IL13Rα2 TanCAR-T cells) were shown to induce higher levels of cytolysis against autologous glioblastoma multiforme (GBM) cells compared to single targeted HER2.CAR- or IL13Rα2.CAR-T cells, dual CAR-T cells co-expressing the anti-HER2 and anti- IL13Rα2 CARs, or a mixture of HER2.CAR- and IL13Rα2.CAR-T cells (pooled CAR-T cells). This evidence concerns the gene IL13RA2 and glioblastoma.