Previous studies indicates that ACSS2 is implicated in numerous biological processes, including lipid metabolism, oxidative phosphorylation, and histone acetylation (Schug et al., 2016), and is significantly associated with development and prognosis of various cancers such as glioblastoma and liver cancer (Sun et al., 2017; Ciraku et al., 2022). This evidence concerns the gene ACSS2 and cancer.