ACSS2 and hepatocellular carcinoma: In hepatocellular carcinoma cells with high ACSS2 expression, acetate enhances the acetylation levels of H3K9, H3K27, and H3K56 in the promoter region through ACSS2, promoting lipid de novo synthesis by upregulating ACC and FASN expression, thus enhancing tumor cell survival under hypoxic conditions (Chen et al., 2017).