To explore the association between ACSS2 and melanoma development, we initially assessed the expression of ACSS2 in a panel of eight human melanoma cell lines at different clinical stages (WM793B, WM35 at primary stage and MM34, A2058, UACC257, A375, 451LU, 1205Lu at metastatic stage) and human melanocytes cell line (NHEM). Here, ACSS2 is linked to melanoma.