Given the established connection between the Hippo pathway and melanoma progression (Lamar et al., 2012; Lamar et al., 2019; Thompson, 2020; Zhang et al., 2020; Tan et al., 2021; Zhao et al., 2021), we hypothesized that ACSS2 could promote melanoma progression through the regulation of the Hippo pathway. The gene discussed is ACSS2; the disease is melanoma.