Moreover, the silencing of HOTAIR (si-HOTAIR) in NSCLC-resistant cell lines to cisplatin increased the sensitivity to chemotherapy by reducing the protein expression levels of wingless integrated 3a (Wnt3a), β-catenin and Adenomatous Polyposis Coli (APC), key regulators of the Wnt signalling pathway (Guo et al., 2018). Here, APC is linked to non-small cell lung carcinoma.