JMJD6 silencing can induce radiosensitivity of LC cells by HOTAIR and ERK2 inhibition suggesting that the JMJD6-BRD4 complex and HOTAIR-LSD1-ERK2 axis play a crucial role in the irradiation tolerance of LCSCs (Pei et al., 2023). Here, MAPK1 is linked to laryngotracheoesophageal cleft.