Furthermore, the knockdown of HOTAIR in irradiated CRC cells led to a decreased expression of metalloproteinase 2 (MMP2) and metalloproteinase 9 (MMP9) suggesting a role of HOTAIR in influencing the invasion and migration of colon cancer cells after irradiation (Yang et al., 2016). The gene discussed is HOTAIR; the disease is malignant colon neoplasm.