This mechanism is capable to induce docetaxel (Doc) resistance in both C4-2 PCa cells and in vivo animal models (N. Wang et al., 2020); 2) in bladder transitional cell carcinoma tissue (TCC), as well as in T24 and J82 cell lines, overexpression of HOTAIR led to an increase in cell proliferation, inhibition of chemosensitivity to doxorubicin, in addition to a reduction in the rate of apoptosis. The gene discussed is HOTAIR; the disease is posterior cortical atrophy.