Mechanistically, HOTAIR suppressed miR-217 expression and increased the expression of glypican-5 (GPC5) and Protein Tyrosine Phosphatase Non-Receptor Type 14 (PTPN14) promoting paclitaxel and doxorubicin resistance in GC cells (H. Wang et al., 2018a). Here, GPC5 is linked to gastric cancer.