HOTAIR can also repress two crucial target genes, Calcium Binding And Coiled-Coil Domain 1 (CALCOCO1) and zinc finger CCCH-type containing 10 (ZC3H10), directly involved in the modulation of sensitivity to TMZ in U251 glioma cells (Lei Zhang et al., 2020c). The gene discussed is CALCOCO1; the disease is central nervous system cancer.