Among them, HOTAIR plays a critical role in both the initiation and progression of different types of human cancers, as well as in the modulation of resistance mechanisms, facilitated also by its functional interactions with different miRNAs (Bhan and Mandal, 2015; Cantile et al., 2021; Liguori et al., 2021; Xin et al., 2021). This evidence concerns the gene HOTAIR and cancer.