HOTAIR is overexpressed in both cisplatin-resistant tissues and cell lines of nasopharyngeal carcinoma (NPC) and its silencing increased sensitivity to cisplatin in DDP-resistant NPC cells, suppressed cell viability, invasion, and migration, and promoted apoptosis by modulating the activity of the miR-106a-5p/SOX4 axis (Cao et al., 2022). The gene discussed is SOX4; the disease is nasopharyngeal carcinoma.