Based on a meta-analysis of 16 studies with SCH, hormonal therapy ameliorated several surrogates of endothelial function and arterial stiffness [total cholesterol and LDL-c level, C-reactive protein (CRP), brain natriuretic peptide (BNP), and flow-mediated dilatation (FMD)], suggesting a potential positive impact of L-T4 on the CV system (42). Here, CRP is linked to spindle cell hemangioma.