INS and obesity due to melanocortin 4 receptor deficiency: Shifting our focus to obesity-related blood variables, significant reductions were observed in the ExC group for total cholesterol (TC) (10.9%, p < 0.001), high-density lipoprotein (HDL) (12.1%, p < 0.05), glucose (9.2%, p < 0.05), insulin (30.5%, p < 0.05), and the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (38.7%, p < 0.05).