There are numerous etiologies for hereditary kidney cancer, including von Hippel-Lindau (VHL) disease, hereditary leiomyomatosis and renal cell carcinoma (HLRCC), hereditary papillary renal cell carcinoma type 1 (HPRCC1), Tuberous Sclerosis Complex 1/2 (TSC1/2), Birt-Hogg-Dube disease (BHD), and other related genetic disorders (6). Here, TSC1 is linked to hereditary leiomyomatosis and renal cell cancer.