Expression analysis revealed that ITGA5 (TCGA glioma: WHO IV vs. WHO II, ***p < 0.001, WHO IV vs. WHO III, ***p < 0.001; Rembrandt glioma: WHO IV vs. WHO II, ***p < 0.001, WHO IV vs. WHO III, ***p < 0.001) and ITGAV (TCGA glioma: WHO IV vs. WHO II, ***p < 0.001, WHO IV vs. WHO III, *p < 0.05; Rembrandt glioma: WHO IV vs. WHO II, ***p < 0.001, WHO IV vs. WHO III, ***p < 0.001) were highest in GBM (Figure S2A,B). This evidence concerns the gene ITGA5 and central nervous system cancer.