Further protein microarray data analysis showed that the inhibitory effects of COL6A1 on GBM may be associated with ECM‐related functions, particularly some proteins involved in cell adhesion, such as fibronectin, Caveolin 1, IGFBP2, and paxillin, that could promote tumor cell migration, invasion, and survival.49, 50, 51, 52, 53. This evidence concerns the gene IGFBP2 and glioblastoma.