Based on the differential analysis and enrichment results between COL6A1‐high and ‐low groups in GBM cohorts, COL6A1 may be closely associated with extracellular matrix organization, collagen‐containing extracellular matrix, focal adhesion, and ECM–receptor interaction in GBM (Figure 5A–C). This evidence concerns the gene MMRN1 and glioblastoma.