COL6A1 and central nervous system cancer: Our analyses of TCGA and Rembrandt public datasets revealed that COL6A1 mRNA levels were markedly upregulated with increasing World Health Organization (WHO) grades of glioma (TCGA glioma: WHO IV vs. WHO II, ***p < 0.001, WHO IV vs. WHO III, ***p < 0.001, and WHO III vs. WHO II, ***p < 0.001; Rembrandt glioma: WHO IV vs. WHO II, ***p < 0.001, WHO IV vs. WHO III, ***p < 0.001, and WHO III vs. WHO II, *p < 0.05, Figure 4A,C).