During the course of chronic heart failure (CHF), increased expression of TLR‐4 by monocytes correlates with increased plasma levels of proinflammatory factors such as IL‐1, IL‐6, and TNF, predicting long‐term productivity in patients with CHF, and similar changes in the TLR system of leukocytes occur with advancing age.71 The gene discussed is TLR4; the disease is congestive heart failure.