This suggests that ACE2 and TMPRSS2, while essential to the primary protease‐dependent viral infection route, are not rate‐limiting factors in SARS‐CoV‐2 infection in cultured Calu‐3‐ALIs and that basal co‐expression of the entry proteins was so high in this model that even decreasing expression by up to half (Figure 1) was insufficient to prevent viral entry. The gene discussed is TMPRSS2; the disease is viral infectious disease.