The downregulation of ACE2 and/or TMPRSS2 was insufficient to decrease SARS‐CoV‐2 infectivity, nor did quercetin act as a direct inhibitor of viral entry, demonstrating that a significant decrease in the expression of ACE2 and TMPRSS2 by a promising prophylactic candidate may not translate to infection prevention. The gene discussed is ACE2; the disease is infection.