In addition, IGFBP5 is critically associated with the proliferation and motility of cancer cells and others, such as breast cancer cells,59 glioblastoma,58 nucleus pulposus cells,60 dental pulp stem cells,61 periodontal ligament stem cells and Wharton's jelly of umbilical cord stem cells.62 Here, IGFBP5 is linked to breast carcinoma.