Additionally, IGFBP5 blocks IGF signalling by binding to IGF and preventing its interaction with IGF1R35; once secreted, IGFBP5 works alongside other intracellular feedback mechanisms to inhibit the role of IGF1 and serves as a non‐cell autonomous feedback mechanism for tumours to reduce IGF1R signalling in the adjacent normal cells.51 This evidence concerns the gene IGF1 and neoplasm.