AT2R has been suggested to play a role in cognition,41 and induces anti-inflammatory effects by promoting anti-inflammatory cytokine, such as IL-10, release.42 Furthermore, activation of the AT2R promotes neurite outgrowth and supports neuronal survival in the brain during ischemia.43 Thus, downregulation of the AT2R after hypertension and stroke may result in loss of anti-inflammatory and neuronal survival pathways, leading to worsened outcomes. This evidence concerns the gene IL10 and ischemia.