There is increasing relevance of microRNAs as biomarkers for stroke pathology.35 Indeed, it has been suggested that miR-132 may be a biomarker for mild and post-stroke cognitive impairment,36,37 and overexpression of miR-132 impairs neuroplasticity and short term memory.38 We found Mir132 gene expression was upregulated after stroke in normotensive mice compared with sham and was further upregulated in hypertensive mice after stroke compared with normotensive mice after stroke. Here, MIR132 is linked to Cognitive impairment.