No inclusions were detected in heart, liver, spleen or hilar lymph nodes of neurologically normal individuals aged 71, 75 and 76 years with abundant TMEM106B inclusions in the brain (Fig. 3) or of a 49 year-old familial AD patient whose lung, gut, thyroid, and adrenal gland were also analysed (case 46, Supplementary Table 1). The gene discussed is TMEM106B; the disease is Alzheimer disease.