Abundant filaments made of residues 120-254 of TMEM106B form in an age-dependent manner in human brains [33, 39, 43, 49], including those from individuals with various neurodegenerative conditions, such as AD, PD, DLB, FTDP-17T, FTLD-TDP, limbic-predominant age-related TDP-43 encephalopathy (LATE), pathological ageing and age-related tau astrogliopathy [3, 8, 14, 21, 23, 29, 39, 43, 49]. This evidence concerns the gene TMEM106B and Alzheimer disease.