TMEM106B inclusions were present in the brains from individuals with FTDP-17T (P301L mutation, aged 55y), PDD (aged 57y), AGD (aged 74y), PiD (aged 75y), FTLD-TDP (aged 75y), PSP (aged 78y), PD (aged 82y) and an aged control (98y). This evidence concerns the gene TMEM106B and argyrophilic grain disease.