Transmembrane protein 106B (TMEM106B) was first linked to neurodegenerative diseases, when sequence variations in its gene were identified as a risk factor for frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP), especially in individuals with granulin gene (GRN) mutations [42]. The gene discussed is TMEM106B; the disease is neurodegenerative disease.