TRAF5 and bladder transitional cell carcinoma: Similarly, in bladder cancer (BLCA), the methylation site cg09825327 in the TRAF5 gene (HR: 1.682, 95% CI: 1.136–2.49, P: 0.009355414) was significantly associated with disease risk... These results suggest that variations in methylation sites may play a critical role in cancer development, highlighting an important direction for future research.