ACTA1 and pulmonary fibrosis: Another study recently showed that intratracheal transplantation of human iPSC-AEC2 in the rat model of BLM-induced lung fibrosis 15 days after BLM challenge, was able to reduce disease severity, when fibrosis has already developed, by suppressing both TGF-β and α-SMA expression and decreasing the collagen deposition [163].