Other pro-fibrotic growth factors such as insulin-like growth factor-1 (IGF-1), and cytokines such as IL-4, which favor eliciting a type 2 immune response, also increase IPF [179], along with a reduction in anti-fibrotic factors such as IFN-γ inducible protein-10 (IP-10) [180]. Here, IGF1 is linked to idiopathic pulmonary fibrosis.