iPSCs also, can downregulate the pro-fibrotic growth factors IGF-1,2 [205], and repress several inflammatory mediators during pulmonary fibrosis, including TNF-α, IL-1β, IL-6, inducible nitric oxide synthase (iNOS) and nitric oxide (NO), but also PGE2. The gene discussed is TNF; the disease is pulmonary fibrosis.