Injected AD-MSCs into UUO model rats via tail vein, or intraperitoneally into ischemia-reperfusion injury (IRI) mice resulted to reduce EMT, α-SMA, fibroblast-specific protein 1 (FSP-1), and ameliorate inflammatory response and renal interstitial fibrosis [112, 113]. This evidence concerns the gene S100A4 and ischemia reperfusion injury.