Thus, observed GR downregulation and MR upregulation (Fig. 5b,c,e,f) results in downregulation of the stress response and is conducive to a pro-inflammatory and neurodegenerative status—potentially rendering the asyn PD brain hypersensitive to elevated glucocorticoid levels and subsequent deficit in coping with chronic stress exposure. Here, NR3C2 is linked to Parkinson disease.