P2RX7 and musculoskeletal system disorder: Electromagnetic field therapy has been used to treat bone fractures and musculoskeletal disorders, including osteoarthritis and rheumatoid arthritis, by directly inducing or accelerating the osteogenic differentiation of BM-MSCs associated to overexpression of P2X7 receptors and PKB/GSK3β/β-catenin downstream signalling activation [32].