Several key genes regulating metabolism (including ASNS, SLC1A3, DSC3, ATP6V1C2), transcriptional events and oncogenic signaling (PRKAA2 (also known as AMPK), ANXA10, GNG2, and CSAG1)) were significantly downregulated by ASNS deletion in the female CRC (Fig. 3B). This evidence concerns the gene DSC3 and colorectal carcinoma.