PRKAA2 and colorectal carcinoma: Several key genes regulating metabolism (including ASNS, SLC1A3, DSC3, ATP6V1C2), transcriptional events and oncogenic signaling (PRKAA2 (also known as AMPK), ANXA10, GNG2, and CSAG1)) were significantly downregulated by ASNS deletion in the female CRC (Fig. 3B).