The Cox proportional hazards analysis including age, education, APOE ε4 carriership, baseline MMSE score as co-predictors evidenced that Aβ positivity (CL > 50), having intermediate Aβ load (12 ≤ CL ≤ 50), and a lower baseline MMSE score were associated with increased risk of progression to dementia (HRAβ+ vs Aβ- = 9.91, 95% CI [2.27, 43.32], p = 0.002; HRAβ± vs Aβ- = 4.31, 95% CI [1.06, 17.57], p = 0.042; HRMMSE = 0.45, 95% CI [0.34, 0.61], p < 0.001). The gene discussed is APOE; the disease is dementia.